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Compared with BRD4, significantly less attention is paid to your expression of BRD2 and BRD3, which are also implicated during the regulation of immune reaction. Early studies showed that BRD2 is highly expressed in pancreatic β cells, thus inhibiting mitosis and insulin transcription.24 Recent reports point out that α-synuclein induces BRD2 expression, So initiating the neuroinflammation in Parkinson’s condition.44 The expression of BRD2 (but not BRD3 and BRD4) is dominantly increased through photoreceptor degeneration that occurs postnatally in lipopolysaccharide (LPS)-stimulated mouse Principal astrocytes.
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